In the account of what science is in Science and Explanation I took as my starting point that "an essential part of experience is expectation, that an inseparable component to normal experience is the effort to predict what is to come." In this essay I want to close the hermeneutic circle opened there, and to review some of the leading scientific models of how the mind and our world is related to our brain. Given what we have learned so far in this project about the relationship between reality and representations of it, we can better understand these approaches and what they can and can’t say about the world, model and mind.